Bioinformatics workflow for differential splicing analysis in Alzheimer's disease mouse models (Pandey et al. 2023, BMC Genomics)
Subtype-resolved snRNA-seq analysis of TREM2–amyloid interactions in 5XFAD Alzheimer's mouse model. R/Seurat v5 pipeline: QC, Allen Brain Atlas label transfer (25 subtypes), pseudobulk DESeq2, cross-comparison gene classification (Cat1–6), multi-database ORA/GSEA, and partition analysis.
Unified metabolic collapse framework describing diabetes and Alzheimer’s disease as branched outcomes of the same APOE-TREM2-PSEN1 structural process.
Unified mathematical model of metabolic collapse integrating APOE, TREM2, PSEN1, and OTULIN dynamics based on East Asian genomic statistical structure.
Integrated analytical report on Alzheimer’s disease-related origin structures using public genomic and transcriptomic datasets.
Analysis code for Leon et al.: Nasu-Hakola disease (DAP12-deficient) frontal cortex and hippocampus — snRNA-seq and Visium spatial transcriptomics
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