The aim of this repository is to assist in further improving and expanding the genome-scale human metabolic reconstruction through the use of issues. Please note that pull requests will be automatically closed.
Two benchmark-validity studies of transcriptome-based metabolic reaction activity scoring on Recon3D (joint patient-and-reaction hold-out with input substitution; language-model interventions and external cohorts), the metabench checks, and the MetaGNN scorer they audit
Where transcript evidence stops influencing predicted metabolic exchange: a controlled study of the score-to-cost interface in constraint-based metabolic prediction, its constraint-stage diagnosis, and an independent condition-response evaluation
Computational model exploring how lactate shapes the glioblastoma microenvironment and therapy response
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