hypothalamus

Oral, blood-brain barrier-penetrant agents that soften hypothalamic perineuronal nets to restore insulin signaling in obesity: research notes, data and computational analyses. Free non-commercial research under ASL-1.1; commercial use under ACL-1.0.

This repository contains code to identify expression patterns of genes and cells involved in hypothalamic control of metabolism and stress response. It also performs bioinformatic molecular profile analysis of parvocellular and preautonomic neurons i.e. Crh. Overall, it enables reproducible analysis of biomarkers and ALK / Augα signaling in PVH

Interactive browser for hypothalamic differential expression and pathway enrichment across 162 studies

This repository contains code and output for the reanalysis of dataset from Lutomska LM et al., 2022 for analysis of hypothalamus astrocytes heterogeneity in Tretiakov EO et al., 2023.

This repository supports our 2025 manuscript, Single-Cell Resolution of Individual Variation in Hypothalamic Neurons Allows Targeted Manipulation Affecting Social Motivation